
The evolution of multicellular life from simpler, unicellular microbes was a pivotal moment in the history of biology on Earth. Scientists are still working to understand how and why single cells evolved traits that entrenched them into group behavior, paving the way for multicellular life. One study published in Science Advances found evidence of electrical signaling and coordinated behavior in choanoflagellates, the closest living relatives of animals. This suggests that the ability to coordinate movement at the cellular level predates the first animals and that cellular coordination may have played an important role in the early evolution of animal multicellularity and nervous systems.
| Characteristics | Values |
|---|---|
| Basic electrical signaling | Pre-dates multicellularity |
| Multicellularity | Evolved from unicellular eukaryotes at least 1.7 billion years ago |
| The first multicellular animals appeared 600 million years ago | |
| Unicellular relatives of multicellular species still exist | |
| Multicellularity increases biological complexity | |
| Multicellular organisms perform novel functions that may confer a competitive advantage | |
| Multicellularity may have arisen from the division of labor and specialization of cell types | |
| Multicellularity may have arisen from the collective integration of spatial information |
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What You'll Learn
- The evolution of multicellularity is a way of increasing biological complexity
- Multicellular organisms are built upon the basis of cells, with many cells living within one group
- The evolution of multicellularity required the acquisition of cell–cell adhesion, communication, cooperation, and specialization
- The first multicellular organisms were only a mutation away from being strictly unicellular
- Multicellularity has evolved at least once in every major eukaryotic clade

The evolution of multicellularity is a way of increasing biological complexity
The evolution of multicellularity has been a pivotal moment in the history of biology on Earth, drastically reshaping the planet's ecology. It has evolved independently several times across the tree of life, and complex multicellular organisms have evolved in six eukaryotic groups: animals, symbiomycotan fungi, brown algae, red algae, green algae, and land plants.
The first known single-celled organisms appeared on Earth about 3.5 billion years ago, roughly a billion years after Earth was formed. More complex forms of life took longer to evolve, with the first multicellular animals not appearing until about 600 million years ago. The evolution of multicellularity from simpler, unicellular microbes was facilitated by single cells evolving traits that entrenched them into group behaviour. For example, the bacterium Pseudomonas fluorescens rapidly evolves to generate multicellular mats on surfaces to gain better access to oxygen.
The genetic toolkit and cellular components that allow for multicellularity pre-date multicellular species and are found in their unicellular relatives. Aggregates of cells can organise themselves by exploiting these old components in a new multicellular context, allowing them to perform novel functions or perform old functions in novel ways that may confer some competitive advantage over single cells. Greater complexity can later evolve by coordinating the division of tasks between different cell lineages of the same organism, giving rise to embryonic development.
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Multicellular organisms are built upon the basis of cells, with many cells living within one group
The first known single-celled organisms appeared on Earth about 3.5 billion years ago, roughly a billion years after Earth formed. More complex forms of life took longer to evolve, with the first multicellular animals not appearing until about 600 million years ago. The evolution of multicellular life from simpler, unicellular microbes was a pivotal moment in the history of biology on Earth and drastically reshaped the planet's ecology.
The transition from unicellular to multicellular life has occurred at least 25 times throughout evolution, contributing to a complex tree of species, including plants, fungi, amoeba, and Bilateria, to name a few. Scientists are discovering ways in which single cells might have evolved traits that entrenched them into group behaviour, paving the way for multicellular life. For example, groups of microbes that secrete useful molecules that all members of the group can benefit from can grow faster than groups that do not.
The genetic toolkit and cellular components that allow for multicellularity pre-date multicellular species and are found in their unicellular relatives. Aggregates of cells can organise themselves by exploiting these old components in a new multicellular context, allowing them to perform novel functions or perform old functions in novel ways that may confer some competitive advantage over single cells. Greater complexity can later evolve by coordinating the division of tasks between different cell lineages of the same organism, giving rise to embryonic development.
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The evolution of multicellularity required the acquisition of cell–cell adhesion, communication, cooperation, and specialization
The evolution of multicellularity is a significant transition in individuality, from autonomously replicating cells to groups of interdependent cells forming a higher-level organization. This transition has occurred at least once in every major eukaryotic clade and numerous times among prokaryotes.
For multicellularity to evolve, cells needed to acquire specific characteristics, including cell–cell adhesion, communication, cooperation, and specialization. These traits allowed cells to form aggregates and perform novel functions, increasing their complexity and fitness.
Cell–cell adhesion is a critical factor in the evolution of multicellularity. Aggregates of cells can organize themselves by exploiting adhesion proteins, which are also found in their unicellular relatives. Cells can evolve their adhesion to others in response to environmental changes, such as the need for better access to oxygen or resources.
Communication and cooperation are also essential. Cells can communicate through chemical signalling, such as chemotaxis, where they sense and respond to chemical signals in their environment. Cooperation among cells can reduce starvation, provide protection, and increase the acquisition and utilization of resources.
Additionally, specialization plays a crucial role in the evolution of multicellularity. Functional specialization allows for large-scale integration of environmental cues and the division of labour, where different cell lineages within an organism perform specific functions, increasing overall efficiency and complexity.
The evolution of these characteristics enabled the transition from unicellular to multicellular life, leading to the emergence of complex multicellular organisms with novel functions and capabilities.
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The first multicellular organisms were only a mutation away from being strictly unicellular
The evolution of multicellular organisms from single-celled microbes was a pivotal moment in the history of biology on Earth. The first multicellular organisms were only a mutation away from being strictly unicellular.
The evolution of multicellularity is a way of increasing biological complexity by taking what were formerly free-living individuals and turning them into parts of a new kind of individual: a multicellular organism. The transition from unicellularity to multicellularity has occurred at least 25 times throughout evolution, contributing to a complex tree of species, including plants, fungi, amoeba, and Bilateria. Multicellular organisms are built upon the basis of cells, with many cells living within one group and functioning collectively.
The genetic toolkit and the cellular components that allow for multicellularity, including adhesion proteins, predate multicellular species and are found in their unicellular relatives. Aggregates of cells can organise themselves by exploiting these old components in the new multicellular context, allowing them to perform novel functions or perform old functions in novel ways that may confer some competitive advantage over single cells. For example, the bacterium Pseudomonas fluorescens rapidly evolves to generate multicellular mats on surfaces to gain better access to oxygen. However, once a mat has formed, individual cells may have an incentive to cheat and not produce the glue responsible for mat formation, ultimately leading to the mat's destruction.
Scientists are discovering ways in which single cells might have evolved traits that entrenched them into group behaviour, paving the way for multicellular life. Experiments have shown that a group of microbes that secrete useful molecules that all members of the group can benefit from can grow faster than groups that do not. This is an example of a "ratcheting mechanism", a trait that provides benefits in a group context but is detrimental to loners, ultimately preventing a reversion to a single-celled state.
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Multicellularity has evolved at least once in every major eukaryotic clade
Multicellularity is a kind of organism built upon the basis of cells, where many cells live within one group and function collectively. The evolution of multicellularity is a way of increasing biological complexity by taking what were formerly free-living individuals and turning them into parts of a new kind of individual: a multicellular organism.
The first known single-celled organisms appeared on Earth about 3.5 billion years ago, roughly a billion years after Earth formed. More complex forms of life took longer to evolve, with the first multicellular animals not appearing until about 600 million years ago. The evolution of multicellular life from simpler, unicellular microbes was a pivotal moment in the history of biology on Earth and has drastically reshaped the planet's ecology.
Multicellularity has evolved independently at least 25 times in eukaryotes, and also in some prokaryotes, like cyanobacteria, myxobacteria, actinomycetes, Magnetoglobus multicellularis, or Methanosarcina. However, complex multicellular organisms evolved only in six eukaryotic groups: animals, symbiomycotan fungi, brown algae, red algae, green algae, and land plants. It evolved once for animals, once for brown algae, three times in the fungi (chytrids, ascomycetes, and basidiomycetes), and perhaps several times for slime molds and red algae.
The evolution of multicellularity required the acquisition of cell-cell adhesion, communication, cooperation, and specialization. The genetic toolkit and the cellular components that allow for multicellularity, including adhesion proteins, pre-date multicellular species and are found in their unicellular relatives.
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Frequently asked questions
Electrical signaling is the process by which information flows between cells, allowing them to coordinate their behavior and perform complex functions.
Electrical signaling is achieved through the dynamic control of free cytoplasmic calcium concentrations and the modulation of entry, release, and clearance. Calcium acts as a signaling molecule, triggering a rapid response in excitable cells, such as neurons and muscle cells.
Multicellularity refers to organisms that are composed of multiple cells working collectively as a single organism. This allows for increased biological complexity and the division of labor, enabling functions that would not be possible for single-celled organisms.
Evidence suggests that basic electrical signaling may have evolved before multicellularity. Choanoflagellates, the closest living relatives of animals, exhibit electrical signaling and coordinated behavior through voltage-gated calcium channels. This discovery provides insights into the early evolution of animal multicellularity and nervous systems, indicating that cellular coordination and communication systems may have predated the first animals.











































